منابع مشابه
Overview of oncofetal antigens in cancer.
Oncofetal antigens are substances which are produced by tumors and also by fetal tissues but they are produced in much lower concentration by adult tissues. The oncofetal antigens which have been identified are reviewed. The relevance of alpha - 1 - fetoprotein (AFP) and carcinoembryonic antigen (CEA) in neoplastic disease are summarized. Elevated serum concentrations of AFP have been principal...
متن کاملMonoclonal Antibodies against Oncofetal Mucin Ml Antigens Associated with Precancerous Colonie Mucosae1
We obtained seven monoclonal antibodies (MAb) against a gastric min-in of an ALeb patient. By immunoperoxidase on normal gastric mucosae, two MAbs (3-3A and 2-25LE) reacted exclusively with the A and Lewis-positive individuals, respectively; the five other MAbs (1-13 Ml, 2-11 Ml, 2-12 Ml, 9-13 Ml, and 58 Ml) stained the mucus cells of surface gastric epithelium independently of ABO or Lewis sta...
متن کاملMonoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucosae.
We obtained seven monoclonal antibodies (MAb) against a gastric mucin of an ALeb patient. By immunoperoxidase on normal gastric mucosae, two MAbs (3-3A and 2-25 LE) reacted exclusively with the A and Lewis-positive individuals, respectively; the five other MAbs (1-13 M1, 2-11 M1, 2-12 M1, 9-13 M1, and 58 M1) stained the mucus cells of surface gastric epithelium independently of ABO or Lewis sta...
متن کاملOncofetal antigen in Xiphophorus detected by monoclonal antibodies directed against melanoma-associated antigens.
Monoclonal antibodies (MAbs) directed against Xiphophorus melanoma cells were developed and tested by indirect immunofluorescence and immunoperoxidase staining for reactivity with a panel of 15 allogeneic tissues and 12 allogeneic cell lines. The reactivity of such MAbs was restricted to melanoma cells from tumor biopsies and melanoma-derived cell lines. In addition, all embryonic cells of all ...
متن کاملOncofetal fibronectin in diabetic retinopathy.
PURPOSE Imbalance between extracellular matrix protein synthesis and degradation is a key feature of diabetic retinopathy. Fibronectin, a predominant constituent of the extracellular matrix, has been shown to undergo alternative splicing to produce embryonic isoforms in various pathologic conditions, such as fibrotic diseases and tumorigenesis. Two such isoforms, oncofetal fibronectin variants ...
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ژورنال
عنوان ژورنال: Nature
سال: 1986
ISSN: 0028-0836,1476-4687
DOI: 10.1038/319428c0